The administration of maintenance intravenous fluid therapy (MIVFT) is a standard of care for many hospitalized children, especially those admitted in Pediatric Intensive Care Unit (PICU). Currently, MIVFT prescriptions are still often based on Holliday and Segar’s historical guidelines. However, this practice has been associated with several, potentially severe, complications such as hyponatremia, overhydration and hyperchloremic acidosis, due to inappropriate fluid composition and/or infusion rates. The European wide group (as part of the European Society for Pediatric and Neonatal Intensive Care’s, Metabolic, Endocrine and nutrition section) is undertaking a systematic review, evidence synthesis and meta-analysis to develop evidence-based recommendations around the amount and fluid type for MIVFT.
Team: Chief Investigators: Prof Frederic Valla (Hon Professor University of Salford) and Dr David Brossier. Dr Lyvonne Tume at University of Salford is a co-investigator and group lead, a further 30 clinical and methodologists are co-investigators in this project.