Cardio-Respiratory Physiology and Pathology

All members share a common goal; to undertake highly translational laboratory-based cardiovascular research. Revealing detailed patho-physiological mechanisms at cell / tissue level underpins the group’s main agendas:

(1) advance understanding of the fundamental physiology of the cardiovascular system and

(2) discover novel therapeutic targets to prevent or treat cardiovascular disease. The Greensmith lab uses cutting-edge physiological techniques to reveal the detailed cellular basis of heart disease and drug-induced cardiac toxicity, focusing on the role of oxidative stress and inflammation.

The Withers lab places focus on obesity seeking to understand how overweight state can alter vascular function in order to identify new and effective therapies. This group also focusses on secretion biology (secretion, exocytosis, intracellular trafficking) in lung diseases (Miklavc), fungal allergens in airway fibrosis, asthma (Namvar), cellular pathology and pathogenesis of host-pathogen interactions, inflammation and lung fibrosis (Allen and Smyth).

Research is supported by British Lung Foundation, KidsCan, collaboration with Royal Manchester Children’s Hospital and Salford Royal Hospital.