Cancer Disease, Diagnostics and Therapies

This ‘bench-to-bedside’ area works from cells to clinical trials to improve the diagnosis and management of a broad range of human cancers. Cancer research areas in the centre include investigation of inflammation and steroids, p53 tumor suppressor (Krstic-Demonacos), obesity, mitosis (Topham), cancer RNA biomarkers, genomics, genetics (Mukhopadhyay) and cancer nanobiotechnology (Krpetic). In addition, cancer research in the centre is focussed on leukemia/haematology, bioinformatics, transcription factors (Krstic-Demonacos, Aziz), childhood cancers, lung health (Arrigo, Namvar, Smyth, Topham, Krstic-Demonacos).

Several groups have interest in designing and synthesising of novel compounds for cancer therapies. This includes free radicals, chromatography, mass spectrometry, biomarkers (Podmore), medicinal chemistry, cancer, glycomimetics (Wilkinson, Rossington), and nanotechnology (Krpetic) as well as computer modelling techniques/chemistry (Akinshina) and glycobiology, drug design and discovery, molecular modelling, tumour angiogenesis (Pye).

Numerous collaborations at the international level include Vietnam, Thailand and Japan, Italy and USA and many others. Numerous researchers collaborate and are funded through joint grants with local hospitals such as Blackpool Victoria Teaching Hospital, Royal Manchester Children’s Hospital and Wythenshawe Hospital. In addition, KidsCan Charitable Trust funds several BRC members research into childhood cancer.