Viruses turbo-charge bacterial evolution in cystic fibrosis infections

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SCIENTISTS in the UK have found new evidence that tiny viruses called bacteriophages turbo-charge the evolution of bacteria that cause lung infections in Cystic Fibrosis patients.

And they say because antibiotics can activate bacteriophages, certain medical therapies might make the infections even more difficult to treat.

Cystic Fibrosis (CF) patients suffer from life-long lung infections caused by the environmental bacterium Pseudomonas aeruginosa. These infections worsen patient health and limit life-expectancy. Over the years of the infection, the bacteria evolve to become better adapted to the lung environment, becoming very difficult to treat. Scientists in the UK have found new evidence that viruses infecting the bacteria, called bacteriophages, can speed-up this bacterial evolution.

A team of scientists from the Universities of Liverpool, Salford and York evolved populations of the bacterium P. aeruginosa with or without bacteriophages in a growth medium designed to replicate the sputum in CF lungs. They then tracked evolutionary change in the bacterium using genome sequencing.

Useful mutations

The study, published in the Proceedings of the National Academy of Sciences, reports that bacteria with bacteriophages evolved faster to adapt to life in sputum. This happened because the bacteriophage jumped into the bacterium’s DNA, increasing the number of useful mutations that natural selection could use.

Many of the mutations seen in the lab-evolved bacteria, including those caused by the bacteriophage, are also commonly seen in bacteria isolated from CF infections. Because bacteriophages live wherever you find bacteria, including in the lungs of CF patients, this could mean that they play an important role in bacterial evolution in the clinic.

Dr Chloe James, lecturer in Medical Microbiology at the University of Salford, said: “We knew from our previous work that the bacteriophages infecting P. aeruginosa were commonly found in CF patient sputum. We now know that these bacteriophages can speed up evolution helping bacteria adapt to living in a sputum-like environment.”

Prof Craig Winstanley, of the University of Liverpool, said: “Because some antibiotics can activate bacteriophages, some antibiotic therapies might help bacteria to adapt to the lung faster making the infections even more difficult to treat.”

Improved treatments

Prof Michael Brockhurst, of the University of York, added: “To design better treatments and preserve our antibiotics we urgently need to better understand how bacteria evolve in infections. These new results suggest that bacteriophages may play a much bigger role than previously thought, by turbo-charging evolutionary adaptation.”

Notes:

‘Temperate phages both mediate and drive adaptive evolution in pathogen biofilms’ is published on July 4, 2016 in the Proceedings of the National Academy of Sciences, and authored by Emily Davies 1,2, Chloe James 1,3,, David Williams 1,2,, Siobhan O’Brien 4, Joanne Fothergill 1, Sam Haldenby 2, Steve Paterson 2, Craig Winstanley 1, Michael A. Brockhurst 4,

1.    Institute of Infection and Global Health, University of Liverpool, Liverpool, UK

2.    Institute of Integrative Biology, University of Liverpool, Liverpool, UK

3.    School of Environment and Life Sciences, University of Salford, Manchester, UK

4.    Department of Biology, University of York, York, UK

PNAS provides journalists with access to embargoed manuscripts through EurekAlert!. Journalists should register with EurekAlert! at http://www.eurekalert.org/register.php and request access to PNAS materials. If they are already registered with EurekAlert!, they can request access to PNAS athttp://www.eurekalert.org/account.php.

For more about Cystic Fibrosis, go to https://statistics.blf.org.uk/cystic-fibrosis or https://www.cysticfibrosis.org.uk/

Andy Miah
Chair in Science Communication & Future Media
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